ABSTRACT
Brucellosis is the most common zoonotic infectious disease in the world.The main host is animals,and human being is the second main host.Sheep are the main source of infection in China.Brucella can invade all systems of human body,its clinical manifestations are varied,and the invasion of the nervous system is "neurological brucellosis (NB)".It is relatively rare,and complicated which can be meningitis,meningoencephalitis,acute cerebrovascular disease,epilepsy and so on.Be cause of this,the clinical diagnosis become difficult,also,it is easy to misdiagnose.Although the fatality rate of NB is low,misdiagnosis or treatment is not timely,it will lead to lifelong disability.In order to promote the understanding and attention of the clinicians in neurobrucellosis,the pathogenesis,epidemiology,clinical features,auxiliary examination,diagnosis,treatment and prevention prognosis are summed and some suggestions will be given in this review about the diagnosis and treatment of neuronal brucellosis aiming to solve the problems exist in China.